Charles H Cha, MD, FACS

Associate Professor of Surgery (Oncology and Gastrointestinal)

Research Organizations

Cancer Center, Yale: Developmental Therapeutics

Developmental Therapeutics

Surgery: Oncology/General Surgery

Research Summary

Dr. Cha has established an active research laboratory studying the effects of angiogenesis on colorectal and liver malignancy using gene-silencing techniques to silence angiogenic factors leading to decreased tumor growth. He collaborates with a number of Yale researchers to use nanoparticle delivery systems to target tumor cells before they can grow larger than a few millimeters in size. His laboratory effort has resulted in support from a number of funding sources including the Hartford Foundation, American College of Surgeons Faculty Research Award, Ohse Foundation, and the VA Healthcare System Career Development Award. His clinical research interests include the determination of the diagnostic and therapeutic utility of angiogenic inhibitors for treatment of colorectal and liver cancers. In addition, he is involved in clinical outcomes research in surgery for liver, gastric, esophageal and colorectal malignancy using the National Surgical Quality Improvement Program Database as well as the Connecticut Tumor Registry. In his lab, Dr. Cha has mentored a number of medical students, surgical residents, fellows and postdoctoral students including Steve Ward, MD, Abby Mulkeen, MD, Peter Yoo, MD, Sharon Kiang, MD, and Wenli Gao, PhD., leading to over 20 publications and honors such as Best Resident Paper at the New England Surgical Society (Mulkeen), Ohse Foundation Award (Mulkeen, Yoo), Pfizer/ACS Travel Scholarship (Yoo), Best Case Presentation Connecticut Chapter, ACS (Yoo), NIH LRP Award (Yoo).

Extensive Research Description

Dr. Cha has established an active research laboratory studying the effects of angiogenesis on colorectal and liver malignancy using gene-silencing techniques to silence angiogenic factors leading to decreased tumor growth. He collaborates with a number of Yale researchers to use nanoparticle delivery systems to target tumor cells before they can grow larger than a few millimeters in size. His laboratory effort has resulted in support from a number of funding sources including the Hartford Foundation, American College of Surgeons Faculty Research Award, Ohse Foundation, and the VA Healthcare System Career Development Award. His clinical research interests include the determination of the diagnostic and therapeutic utility of angiogenic inhibitors for treatment of colorectal and liver cancers. In addition, he is involved in clinical outcomes research in surgery for liver, gastric, esophageal and colorectal malignancy using the National Surgical Quality Improvement Program Database as well as the Connecticut Tumor Registry. In his lab, Dr. Cha has mentored a number of medical students, surgical residents, fellows and postdoctoral students including Steve Ward, MD, Abby Mulkeen, MD, Peter Yoo, MD, Sharon Kiang, MD, and Wenli Gao, PhD., leading to over 20 publications and honors such as Best Resident Paper at the New England Surgical Society (Mulkeen), Ohse Foundation Award (Mulkeen, Yoo), Pfizer/ACS Travel Scholarship (Yoo), Best Case Presentation Connecticut Chapter, ACS (Yoo), NIH LRP Award (Yoo).

Selected Publications

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Contact Info

Charles H Cha, MD, FACS
Patient Care Locations
Yale Surgical OncologySmilow Cancer Hospital at Yale - New Haven
35 Park Street, Ste 8th Floor Multispecialty Care Center

New Haven, CT 06511
West Haven VA- Department of SurgeryVA Connecticut Healthcare
950 Campbell Avenue, Ste MC 112

West Haven, CT 06516
Farnam Memorial Building
310 Cedar Street

New Haven, CT 06510
Office Location
Laboratory for Medicine and Pediatrics
15 York Street, Ste 130

New Haven, CT 06510
Mailing Address
PO Box 208062
New Haven, CT 06520-8062

Curriculum Vitae