Charles H. Cha, M.D.

Assistant Professor

Surgical Specialty

Gastrointestinal and Oncologic/General Surgery

Clinical Interests

Surgery for benign and malignant disease of the liver, bile duct and pancreas. Surgery for gastric and esophageal cancer, sarcoma. Minimally invasive surgery (robotic and laparoscopic) for cancer.

Research Interests

Effects of angiogenesis on gastrointestinal malignancy. Investigation of gene silencing techniques to knockdown proliferation of hepatocellular carcinoma in vitro and in vivo. Determination of the diagnostic and therapeutic utility of angiogenic inhibitors for treatment of solid tumors. Clinical outcomes in surgery for sarcoma, hepatobiliary, gastric and esophageal malignancy.

Dr. Cha's Research Laboratory

Dr. Cha has established an active research laboratory studying the effects of angiogenesis on colorectal and liver malignancy using gene-silencing techniques to silence angiogenic factors leading to decreased tumor growth. He collaborates with a number of Yale researchers to use nanoparticle delivery systems to target tumor cells before they can grow larger than a few millimeters in size. His laboratory effort has resulted in support from a number of funding sources including the Hartford Foundation, American College of Surgeons Faculty Research Award, Ohse Foundation, and the VA Healthcare System Career Development Award. His clinical research interests include the determination of the diagnostic and therapeutic utility of angiogenic inhibitors for treatment of colorectal and liver cancers. In addition, he is involved in clinical outcomes research in surgery for liver, gastric, esophageal and colorectal malignancy using the National Surgical Quality Improvement Program Database as well as the Connecticut Tumor Registry.

In his lab, Dr. Cha has mentored a number of medical students, surgical residents, fellows and postdoctoral students including Steve Ward, MD, Abby Mulkeen, MD, Peter Yoo, MD, Sharon Kiang, MD, and Wenli Gao, PhD., leading to over 20 publications and honors such as Best Resident Paper at the New England Surgical Society (Mulkeen), Ohse Foundation Award (Mulkeen, Yoo), Pfizer/ACS Travel Scholarship (Yoo), Best Case Presentation Connecticut Chapter, ACS (Yoo), NIH LRP Award (Yoo).

Board Certification:	American Board of Surgery, 2002
Education:	B.S., Northwestern University, Evanston, IL, 1990 M.D., Honors, Northwestern University Medical School, 1995
Training:	Resident: General Surgery, University of Wisconsin Hospital and Clinics, Madison, WI 1999 Chief Resident: General Surgery, University of Wisconsin Hospital and Clinics, Madison, WI 2001 Fellow: Oncology and Surgery, University of Wisconsin Comprehensive Cancer Center 1999 Clinical Fellow: Surgical Oncology, Memorial Sloan-Kettering Cancer Center 2003

Curriculum Vitae

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Contact

Office Address
Department of Surgery
Yale University School of Medicine
P.O. Box 208062
New Haven, Connecticut 06520-8062

E-mail
charles.cha@yale.edu

Office Phone
(203) 785-2380

Fax
(203) 737-4067