Abeel A. Mangi MD

Associate Professor of Surgery (Section of Cardiac Surgery); Surgical Director, Center for Advanced Heart Failure, Mechanical Circulatory Support and Heart Transplantation; Surgical Director, Trans-Catheter Therapies

Biographical Info

Abeel A. Mangi, MD, is an attending surgeon in the Section of Cardiac Surgery at Yale University, and is Surgical Director of the Center for Advanced Heart Failure, Mechanical Circulatory Support and Cardiac Transplantation at the Yale New Haven Heart & Vascular Institute. He is also Surgical Director of the Program in Trans-Catheter Therapies.

Dr. Mangi is certified by the American Board of Surgery, and by the American Board of Thoracic Surgery. He is Associate Professor of Surgery at the Yale University School of Medicine.

He specializes in complex and re-operative cardiac surgery, heart, heart-lung, and lung transplantation, ventricular assist devices, total artificial hearts, extracorporeal membrane oxygenation (ECMO), operations for heart failure, aortic and mitral valve repair and replacement, off-pump coronary bypass grafting, myectomy and the surgical treatment of hypertrophic cardiomyopathy, treatment of chronic pulmonary emboli, and ascending aortic and arch replacement.

Dr. Mangi has performed over 2,000 heart operations. His accomplishments include pioneering one of the first uses of VA-ECMO in an awake, ambulating patient as a successful bridge to lung transplantation; recognizing the importance of surgical technique in avoiding LVAD failure; and investigating comparative cost-effectiveness of therapies for advanced heart failure. Under his leadership, volume of the transplant and mechanical circulatory support programs has quadrupled; while length of stay, morbidity and mortality have decreased, and quality has increased.

Dr. Mangi earned his undergraduate and medical degrees from Brown University. After completing his residency in general surgery at the Massachusetts General Hospital & Harvard Medical School, he was awarded a postdoctoral National Research Service Award fellowship, and won awards from the American Heart Association and the American College of Cardiology for ground-breaking stem cell research done at the Brigham & Women's Hospital and Harvard Medical School. He completed his fellowship in cardiac surgery at Columbia University and was then appointed as an Associate Staff Cardiac Surgeon at the Cleveland Clinic.

As principal or co-investigator in several clinical trials and studies, Dr. Mangi has focused his research efforts on his specialty interests, including the surgical treatment of ischemic heart failure, cellular therapy to treat advanced heart damage and expanded roles for left ventricular assist devices (LVADs). He is also interested in quality of care in LVAD patients, and desensitization of recipients awaiting cardiac transplantation. He is involved with three clinical trials investigating catheter-based therapies for valvular heart disease in high risk patients. He has previously led an additional eight clinical trials looking at outcomes of patients supported on newer generation LVADs.

Dr. Mangi’s group investigates important questions regarding variables that influence clinical outcomes for therapies for advanced heart failure. Large national databases such as the Interagency Registry for Mechanical Assisted Circulatory Support (INTERMACS), United Network for Organ Sharing (UNOS), Society for Thoracic Surgeons (STS) and the Nationwide Inpatient Sample (NIS) have been used to analyze cost and cost-effectiveness for such therapies, clinical prediction modeling, diversity and health equity issues, quality of life and access to care.

Dr. Mangi has been invited to speak about his clinical experience and research findings at conferences and symposia worldwide. He is the author or co-author of numerous book chapters on subjects related to his specialty interests, including advances in cardiac intensive care, cardiac surgery, assist devices and treatment of heart failure. He has authored or co-authored seventy published studies and abstracts in peer-reviewed publications, including Circulation, Nature Medicine, The Journal of Thoracic and Cardiovascular Surgery, and The Annals of Thoracic Surgery among others.

Dr. Mangi serves on multiple institutional, national and international committees, scientific advisory boards, and has been elected to membership and fellowship in the most esteemed organizations in his field including the International Society for Heart and Lung Transplantation, The American College of Cardiology, The Society for Thoracic Surgeons, The Society of University Surgeons, and The American College of Surgeons.


Education & Training

BS
Brown University (1993)
M.D.
Brown University (1997)
Intern
Massachusetts General Hospital & Harvard Medical School, Surgery (1997 - 1998)
Resident
Massachusetts General Hospital & Harvard Medical School, Surgery (1998 - 2000)
Research Fellow
Brigham & Women's Hospital & Harvard Medical School, Cardiovascular Gene and Stem Cell Therapy (2000 - 2002)
Senior Resident
Massachusetts General Hospital & Harvard Medical School, Surgery (2002 - 2004)
Fellow
Columbia Presbyterian Medical Center, Cardiac Surgery (2004 - 2007)
Board Certification
Surgery, Board Certified  (2005)
Board Certification
Surgery, Thoracic & Cardiac, Board Certified  (2009)

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