Blood Vessels; Heart; Operations Research; Efficiency, Organizational; Diseases; Health Care
As principal or co-investigator in several dozen clinical trials and studies, Dr. Mangi has focused his research efforts on his specialty interests, including trans-catheter repair and replacement of diseased heart valves; the surgical treatment of ischemic heart failure, cellular therapy to treat advanced heart damage and expanded roles for left ventricular assist devices (LVADs). He is principal investigator on multiple clinical trials investigating catheter-based therapies for valvular heart disease and outcomes of patients supported on newer generation LVADs.
Dr. Mangi’s research investigates important questions regarding variables that influence clinical outcomes for therapies for end-stage cardiac patients – whether those with advanced heart valve disease or advanced heart failure. Large national databases such as the Interagency Registry for Mechanical Assisted Circulatory Support (INTERMACS), United Network for Organ Sharing (UNOS), Society for Thoracic Surgeons (STS) and the Nationwide Inpatient Sample (NIS) have been used to analyze cost and cost-effectiveness for such therapies and clinical prediction modeling. More recently, Dr. Mangi’s work has focused on dynamic work design in the health care delivery environment and optimal rational strategies to decrease costs of care.