Answer:
Integra - a bilaminate membrane consisting of an inner layer of bovine collagen crosslinked with a glycosaminoglycan and an outer layer of Silastic. It is designed to be placed on freshly excised full-thickness burns, and the Silastic layer is replaced with a thin epidermal autograft 2-3 weeks later. It is thought to provide a better cosmetic result than meshed split thickness skin grafts and allows quicker healing of donor sites since more superficial grafts are taken. The take of native graft is thought to be better, however, because of better drainage and quicker vascularization. In addition, subgraft infection can be more difficult to detect with Integra.
Dermagraft - allogenic fibroblasts (isolated from human neonatal foreskin) seeded on to a polygalactan mesh. This mesh is placed on an excised wound and then a meshed skin graft is placed over it immediately which may lessen wound contraction and scarring. The fibroblasts allow generation of a neodermis while the polygalactan mesh degrades over a period of four weeks. A minimal inflammatory reaction has been noted during the dissolution of the mesh.
Alloderm - cadaveric dermal tissue which has been stripped of its epithelial elements, sterilized, and then cryogenically preserved. The resulting dermis is theoretically non-antigenic but contains basement membrane proteins which facilitates epithelialzation. This cadaveric tissue is overlayed with a thin epithelial autograft at the time of excision.
Composite substitutes - dermal substitute with cultured keratinocytes theoretically not requiring any further autografts. Still undergoing clinical and laboratory trials.