3.  Review the Parkland, Moore, Evans, Brooke and hypertonic saline formulas.  What is the rationale for the differences?

Answer:
Formula First 24 hrs Second 24 hrs
electrolyte colloid D5W electrolyte colloid D5W
Moore Isotonic 75cc/%BBSA  75cc/%BBSA 2 liters  1/2 of 1st 24 hrs 1/2 of 1st 24 hrs 2 liters
Evans NS 1cc/kg/%BBSA 1cc/kg/%BBSA 2 liters 1/2 of 1st 24 hrs 1/2 of 1st 24 hrs 2 liters
Brooke LR 1.5cc/kg/%BBSA (If BBSA>50% then use 50%) 0.5cc/kg/%BBSA 2 liters 1/2 of 1st 24 hrs 1/2 of 1st 24 hrs 2 liters
Parkland  LR 4cc/kg/%BBSA  ---- ---- ---- 20-60% of calc plasma volume as needed
Modified Brooke LR 2cc/kg/%BBSA  ---- ---- ---- 0.5 cc/kg/%BBSA as needed
Hypertonic saline 250mEq Na per liter
(BBSA=burned body surface area)

Current thoughts regarding resuscitation:
- no colloid necessary during 1st 24 hours.  Does restore cardiac output faster, but equally effective after 48 hours; deleterious on lung with increased extravascular lung water and increased late complications.
- all formulas are clinically effective, though many patients require modification (e.g. high voltage injuries, delayed resuscitation, inhalation injury, inebriation require more fluid; patients over 50 or with cardiopulmonary disease may need less).
- hypertonic saline may be of value in decreasing volume loading and promoting excretion of potassium in volume sensitive patients.
- plasma volume deficit in 2nd 24 hrs: 0.3-0.5cc/kg/%body surface burned.
 

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