Answer:
Yes. Even in the low concentration found in creams multiple studies have found that histologically there is:
1) decreased corneocyte cohesion by promoting exfoliation on the outer layers of the corneum stratum (thickening of this layer is blamed for photo aging)
2) increased overall epidermal thickness secondary to increased synthesis of glycosaminoglycans and collagen
…leading to:
1) diminishing of fine wrinkles
2) more uniform color
3) decreased laxity of skin
…although it does not affect:
1) pore size or
2) telangectasias