Answer:
Drugs that have been implicated in causing gynecomastia include alcohol, anabolic steroids, amphetamines, chemotherapeutic agents, cimetidine, digitalis, haldol, hydroxyzine, isoniazid, methyldopa, marijuana, opiates, phenothiazines, progestins, reserpine, spironolactone, tricyclic antidepressants.
Nonsurgical therapy should be aimed at correcting any reversible causes, especially when related to medications, and treatment of any serious
underlying disorders that are discovered, especially tumors. Medical treatment aimed at reducing the effective estrogen/androgen ratio, particularly with anti-estrogens, appears to be of some effectiveness. Percutaneous dihydrotestosterone has been shown to moderately effective in treating persistent idiopathic gynecomastia. Tamoxifen shows marginally significant size reduction, but good pain relief in cases of painful idiopathic gynecomastia.