Answer:
Physical findings of the head: turribrachycephaly (coronal suture synostosis); flat, elongated forehead with bitemporal widening and occipital flattening; midface hypoplasia accompanied by orbital proptosis, downslanting palpebral fissures, and hypertelorism. The nose is turned down at the tip, the bridge is depressed, and the septum is deviated. Class III malocclusion.
Associated physical findings: symmetric syndactyly of the hands and feet.
Genetics: most cases sporadic; several autosomal dominant.
Mental status: increased incidence of delayed mental development, but many develop normal intelligence.
Timing: fronto-orbital advancement at age 6-12 months; Le Fort III osteotomy after skeletal maturity is reached at around puberty (others prefer age 4-7 years); secondary midface advancement (Le Fort I) age 14-18 years.