Answer:
Horner's syndrome: Condition that alters the function of the sympathetic innervation of the eye.
Down's syndrome:
1) Epicanthal fold - fold originates in orbital portion of the lid and may extend to base of nose.
2) Oblique lid axis (slanting eye) - upward and outward slanting of the palpebral aperture.
3) Strabismus (unilateral squinting).
Graves' disease:
1) Exopthalmos.
2) Fibrous replacement of the extraocular muscles with imbalance, and finally a fixed gaze.
Neurofibromatosis (also Von Recklinghausen's):
1) Neurofibromas.
2) Bone lesions including an associated anomaly of the greater wing of the sphenoid bone leading to a pulsatile exopthalmos that may occur in the absence of tumor.
Blepharophimosis: Congenital malformation involving the orbital region, usually associated with ptosis of the upper eyelids and epicanthal folds. In addition...
1) Tissues of medial canthal region encroach upon the globe covering the sclera (epiblepharon).
2) Bridge of nose is wide, making eyes seem far apart.
3) Often intercanthal distance is increased (telecanthus).
4) There may be minor degrees of orbital hypertelorism.
5) Diminution of the transverse dimension of the palpebral fissure is accompanied by a diminution in the vertical dimension of the palpebral fissure caused by the eyelid ptosis.
6) There is nearly always absence of the supratarsal fold in the upper eyelid.
7) The eyebrows are highly arched because of the severe ptosis.