Answer:
Klippel-Trenaunay syndrome falls in the category of combined vascular malformations and hypertrophy syndromes. The association of a vascular anomaly with limb hypertrophy was first delineated as a syndrome by Klippel and Trenaunay in 1900. This condition is a combined capillary-lymphatic-venous malformation. In 95% of patients the lower limb is involved, usually unilaterally. In 5%, the upper limb alone is implicated, and in a few patients, the entire trunk is affected. The clinical presentation consists of a cutaneous port-wine stain, varicosities of the greater and lesser saphenous system, increased blood flow in the affected limb, lymphatic hypoplasia presenting as lymphedema and limb hypertrophy.
Maffucci syndrome: defined by the coexistence of a vascular anomaly and dyschondroplasia. In this syndrome, the long bones are foreshortened and deformed with bone exostoses, exophytic venous anomalies are present in the subcutaneous tissues. Twenty percent of these lesions will develop malignant tumors, the most common of which are chondrosarcomas.