24. What does Toradol do to wound healing? (Annals of Plastic Surgery 37:147, 1996)

Answer:
The article cited refers to an animal study from Southern Illinois University.  Wistar rats were treated with intramuscular Toradol (ketorolac) injections one week prior to making a dorsal incisional wound. The wounds were then examined two weeks after wounding and tested for breaking strength and collagen content.  There was a significant decrease in breaking strength and collagen content in the wounds of the rats receiving intramuscular Toradol compared to the wounds in the rats receiving placebo.  The authors concluded that Toradol and non-steroidal anti-inflammatory drugs had a detrimental effect on wound healing by interfering with the inflammatory phase of wound healing.

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