Answer:
Impaired defense of infection at skin and mucous membrane.
High glucose levels favor G+ organisms.
Necrotizing soft tissue infections.
Facultative organisms consume O2 promote growth of obligate anerobes.
Neuropathy increases susceptibility to foot ulcers.
Endoneural edema secondary to osmotic gradient compresses microvasculature of nerve causing ischemia.
Diabetic microvascular disease does not exist. (Incidence same as in general population.)
Most important factor is decreased tissue perfusion.